Eric Verdin, MD
Originally from Belgium, Dr. Verdin earned his MD from the University of Liege, in Belgium. He trained at Harvard Medical School and has held faculty positions at the University of Brussels in Belgium, the NIH in Maryland, and the Picower Institute for Medical Research in New York.
Dr. Verdin studies the molecular virology of HIV and novel approaches to eradicate HIV infection. Dr. Verdin’s laboratory also focuses on a family of proteins—called histone deacetylases—and their role in the aging process and the immune system. He joined the Gladstone Institute of Virology and Immunology in 1997 and became the associate director in 2004.
Dr. Verdin was elected as a fellow of the American Association for the Advancement of Science and as a member of the American Society for Clinical Investigation and the Association of American Physicians. Dr. Verdin serves on the National Scientific Advisory Council of the American Federation for Aging Research and on the Advisory Council of the National Institute of Drug Abuse at NIH. For his aging research, Dr. Verdin was recognized with a Glenn Award for Research in Biological Mechanisms of Aging and a senior scholarship from the Ellison Medical Foundation. His work on HIV was recognized by an Avant-Garde Award from the National Institutes of Health (NIH). Dr. Verdin has served as reviewer on study sections for the NIH, as the organizer of international meetings and as the editor of several books and reviews. He has published more than 200 international papers and is an inventor on 14 published patents.
Veronica graduated with a B.A. in Broadcast Journalism from San Francisco State University. Veronica enjoys live music, cooking, traveling, and playing soccer with her son.
I am French and have a terrific accent, which my friendly co-workers have gradually learned to tolerate. I earned my Ph.D at Paris 7- Denis-Diderot, and I joined Eric Verdin's lab in October 2012. Since then, I have been very busy studying the mechanisms that govern HIV latency in primary cells. Besides the lab, I like hanging out with friends, drinking a good glass of wine, reading, skiing, traveling, playing music and so many other things.
Emilie Besnard is a postdoctoral fellow in the Verdin lab. She is interested in the transcriptional regulation of SIRT3 and its effect on metabolism and aging. She is also working on understanding the regulation of HIV latency. She earned a PhD in molecular and cellular biology at the University of Montpellier in France. Emilie enjoys hiking, biking, watching movies and TV series, trying new restaurants, and generally living in San Francisco.
I'm interested in using my structural biology skills to better understand mitochondrial protein acylation and its regulation by sirtuins. I finished my PhD in Biochemistry in 2013 at the University of Washington under the mentorship of Roland Strong and William Schief, working on protein design and crystallography to study anti-HIV antibodies. My interest in the biology of aging drew me to the Verdin lab, and I hope to some day continue on to a lab of my own. When time allows, I enjoy rock climbing, live music, exploring the city, and spending time with the amazing friends I've made in California.
I got my PhD at Vanderbilt University, Nashville, TN. During graduate school, I studied the role of SIRT1 in promoting cell resistance against oxidative stress in the kidney. Since October 2010, I have been a postdoc in Eric’s lab. My projects focus on investigating the biology of SIRT5 and the two novel lysine modifications SIRT5 removes -succinylation and malonylation. My recent work has characterized the landscape of lysine succinylation in mouse liver mitochondria and strongly supports important roles for SIRT5 and lysine succinylation in regulating fatty acid oxidation and ketone body synthesis.
I have two bachelor’s degrees from the department of Biological Science and the department of Chemistry at Seoul National University in South Korea. My PhD focused on the link between lipid metabolism and metabolic disease in the department of Biological Science, also at Seoul National University. My Postdoc training in Eric’s lab started in July 2012, and I'm currently interested in the regulation of lysine acetylation in the mitochondria and mechanisms of organelle rejuvenation. Besides the lab, I love many kinds of sports (baseball, tennis, golf, badminton, and pingpong), social parties, traveling, and reading. I served as president of the Korean Life Scientists in the Bay Area (KOLIS, which is a huge Korean Scientist Association including UCSF, Stanford, UC Berkeley, and UC Davis) association in 2014.
I did my undergraduate work in biology at Duke University, and got my PhD in immunology from UC Berkeley, working on the regulation of cell death in T cell development in the laboratory of Dr. Astar Winoto. Since joining the Verdin lab, my main area of focus has been elucidating the immunobiology of histone deacetylase 7, an epigenetic regulator with an essential role in the maintenance of immune self-tolerance. With other members of the immunology group, I’m working to define the molecular mechanisms whereby the TCR-dependent nuclear export of HDAC7 mediates both negative thymic selection and the differentiation of agonist-selected innate-like T cell populations. By understanding the important role of HDAC7 in T cell development, we hope to gain new insights into the regulation of immune self-tolerance, and also to identify novel molecular pathways that can be targeted in autoimmune disease. When I’m not pushing back the frontier of human knowledge one miniprep at a time, I like to cook fabulous food for my friends and family, hike through the many splendid landscapes surrounding the Bay Area, and play at being a suburban farmer.
Most of my attention in the lab is focused on understanding how HDAC7 controls the development on innate-like lymphocytes, particularly iNKT cells, and how this might contribute to tissue specific autoimmunity. After spending my entire childhood and adolescence growing up in St. Louis - plus a few more years for a biochemistry degree from Washington University in St. Louis - I moved out to San Francisco in 2009 to start and (eventually) finish the MD/PhD program at UCSF. I spend a lot of time baking for the lab, reading trashy books in secret on my Kindle, and rooting for the Cardinals.
During my PhD studies at Purdue University, I focused on the biology of T cells, where with my colleagues, I discovered that Foxp3+ regulatory T (Treg) cells are present in the germinal center of human lymphoid tissues and serve to suppress both follicular T helper cell (TFH) function and directly suppress B cell immunoglobulin responses. After finishing my PhD, I joined Eric’s laboratory at Gladstone Institutes. Eric has had a long-standing interest in understanding how specific post-translational modifications affect the immune system, so his laboratory was the perfect place to expand my horizons to include the study of epigenetic modifications in immune cell function and T cell differentiation and autoimmune disease. Under his guidance, I have been studying the roles of HDAC7 and SIRT1 in T cell differentiation and autoimmune disease.
I am a Geriatrician who is interested in applying new ideas about the biology of aging and longevity to the clinical care of elders. My undergraduate work was at Yale, after which I completed an MD/PhD at University of Washington in Seattle. I trained in Internal Medicine and Geriatrics at UCSF before returning to basic science. My clinical work is in inpatient Medicine and Geriatrics at the San Francisco VA Medical Center. I am a Beeson Scholar and former Hillblom Postdoctoral Fellow, and have been an Assistant Professor of Geriatrics at UCSF since 2014. Outside of lab, I am an avid volleyball player and long-suffering Mets fan.
Research Associate II
Che-Ping graduated from Iowa state University with a B.S. degree in Biochemistry. Prior to joining the Verdin lab, she studied the roles of microglia, the kyurenine pathway, and the effects of various genetic modifiers in Huntington’s Disease. She is currently assisting Verdin and Ott lab operations and working on SIRT1 related research in Type 1 Diabetes. Che-Ping loves animals, especially dogs (but has no resistance to any kind of furry friend), and is an avid coffee-holic and foodie. She also enjoys experimenting the kitchen, watching great movies, listening to music, traveling and engaging in outdoor activities (especially photography) with her husband.
Peter is a visiting scholar at Gladstone/UCSF, taking a one year sabbatical from his Associate Professor position at the Karolinska Institute. His research focuses on how transcription affects chromatin, and he uses fission yeast as a model system to dissect this interplay mechanistically. He hopes to leverage new discoveries in yeast to better understand how histone turnover may regulate LTR silencing and HIV latency.
Lab Manager / Senior Research Associate
Chia-Lin grew up in Taipei, Taiwan. She received her M.S. in Genetics from UC Davis and B.S. in Agronomy from National Taiwan University. Before joining the Ott lab, she studied the role of chemokine receptor CCR2 in cell signaling and trafficking of monocytes, macrophages, hematopoietic progenitor and stem cells. She is currently the lab manager of Verdin and Ott labs, and works on Type I diabetes, lipid droplets, T-cell senescence all while maintaining the Verdin lab mouse colony. In her free time, Chia-Lin enjoys cooking/baking, jewelry making, reading, playing Chinese music instruments in a Chinese orchestra, and singing in a chamber chorus.