Publications (2010-Current)


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204. Eric Verdin. Review: NAD+ in aging, metabolism, and neurodegeneration. Science. 4 DECEMBER 2015 • VOL 350 ISSUE 6265

 

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203. Nagalingam R. Sundaresan, Samik Bindu, Vinodkumar B. Pillai, Sadhana Samant, Yong Pan, Jing-Yi Huang, Madhu Gupta, Raghu S. Nagalingam, Donald Wolfgeher, Eric Verdin, and Mahesh P. Gupta. SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating GSK3β. Mol. Cell. Biol. doi:10.1128/MCB.00586-15

 

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202. Christopher D. Wiley, Michael C. Velarde, Pacome Lecot, Akos A. Gerencser, Eric Verdin, Judith Campisi. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metabolism 2016 23, 1–12

 

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201. Sang-Won Min, Xu Chen, Tara E Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, Kotaro Shirakawa, S Sakura Minami, Erwin Defensor, Sue Ann Mok, Peter Dongmin Sohn, Birgit Schilling, Xin Cong, Lisa Ellerby, Bradford W Gibson, Jeffrey Johnson, Nevan Krogan, Mehrdad Shamloo, Jason Gestwicki, Eliezer Masliah, Eric Verdin & Li Gan. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature Medicine. VOLUME 21 | NUMBER 10 | OCTOBER 2015 

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200. Nishida Y., Rardin M.J., Carrico C., He W., Sahu A.K., Gut P., Najjar R., Fitch M., Hellerstein M., Gibson B.W., Verdin E. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Mol Cell, 2015. (59(2): p. 321-32. 

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199. Chavez L., Calvanese V., Verdin E. HIV Latency is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. PLoS Pathog, 2015. 11(6) e1004955.

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198. Lim H.W., Kang S.G., Ryu J.K., Schilling B., Fei M., Lee I.S., Kehasse A., Shirakawa K., Yokoyama M., Schnolzer M., Kasler H.G., Kwon H.S., GIbson B.W., Sato H., Akassoglou K., Xiao C., Littman D.R., Ott M., Verdin E. SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med, 2015. 212(5): p. 607-17. 

197. Ruelas D.S., Chan J.K., Oh E., Heidersbach A.J., Hebbeler A.M., Chavez L., Verdin E., Rape M., Greene W.C. MicroRNA-155 Reinforces HIV Latency. J Biol Chem, 2015. 290(22): p. 13736-48. 

196. Zhang, Y., Bharathi, S.S., Rardin, M.J., Uppala, R., Verdin, E., Gibson, B.W., and Goetzman, E.S., SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase. PLoS One, 2015. 10(3): p. e0122297.

195. Verdin, E. and Ott, M., 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol, 2015. 16(4): p. 258-64. 

194. Dahabieh, M.S., Battivelli, E., and Verdin, E., Understanding HIV latency: the road to an HIV cure. Annu Rev Med, 2015. 66: p. 407-21. 

193. Colin, L., Verdin, E., and Van Lint, C., HIV-1 chromatin, transcription, and the regulatory protein Tat. Methods Mol Biol, 2014. 1087: p. 85-101. 

192. Choudhary, C., Weinert, B.T., Nishida, Y., Verdin, E., and Mann, M., The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol, 2014. 15(8): p. 536-50. 

191. Brown, K.D., Maqsood, S., Huang, J.Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., and Jaffrey, S.R., Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss. Cell Metab, 2014. 20(6): p. 1059-68. 

190. Verdin, E., The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan. Nat Med, 2014. 20(1): p. 25-7. 

189. Newman, J.C. and Verdin, E., Ketone bodies as signaling metabolites. Trends Endocrinol Metab, 2014. 25(1): p. 42-52. 

188. Manson McManamy, M.E., Hakre, S., Verdin, E.M., and Margolis, D.M., Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors. Antivir Chem Chemother, 2014. 23(4): p. 145-9. 

187. Newman, J.C. and Verdin, E., beta-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract, 2014. 106(2): p. 173-81. 

186. Novis, C.L., Archin, N.M., Buzon, M.J., Verdin, E., Round, J.L., Lichterfeld, M., Margolis, D.M., Planelles, V., and Bosque, A., Reactivation of latent HIV-1 in central memory CD4(+) T cells through TLR-1/2 stimulation. Retrovirology, 2013. 10: p. 119. 

185. Kang, S.G., Liu, W.H., Lu, P., Jin, H.Y., Lim, H.W., Shepherd, J., Fremgen, D., Verdin, E., Oldstone, M.B., Qi, H., Teijaro, J.R., and Xiao, C., MicroRNAs of the miR-17 approximately 92 family are critical regulators of T(FH) differentiation. Nat Immunol, 2013. 14(8): p. 849-57. 

184. Ott, M. and Verdin, E., Three rules for HIV latency: location, location, and location. Cell Host Microbe, 2013. 13(6): p. 625-6. 

183. Jing, E., O'Neill, B.T., Rardin, M.J., Kleinridders, A., Ilkeyeva, O.R., Ussar, S., Bain, J.R., Lee, K.Y., Verdin, E.M., Newgard, C.B., Gibson, B.W., and Kahn, C.R., Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes, 2013. 62(10): p. 3404-17. 

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182. Rardin, M.J., He, W., Nishida, Y., Newman, J.C., Carrico, C., Danielson, S.R., Guo, A., Gut, P., Sahu, A.K., Li, B., Uppala, R., Fitch, M., Riiff, T., Zhu, L., Zhou, J., Mulhern, D., Stevens, R.D., Ilkayeva, O.R., Newgard, C.B., Jacobson, M.P., Hellerstein, M., Goetzman, E.S., Gibson, B.W., and Verdin, E., SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab, 2013. 18(6): p. 920-33.

181. Verdin, E. and Ott, M., Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell, 2013. 51(2): p. 132-4. 

180. Merksamer, P.I., Liu, Y., He, W., Hirschey, M.D., Chen, D., and Verdin, E., The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY), 2013. 5(3): p. 144-50. 

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179. Ho, L., Titus, A.S., Banerjee, K.K., George, S., Lin, W., Deota, S., Saha, A.K.,  Nakamura, K., Gut, P., Verdin, E., and Kolthur-Seetharam, U., SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY), 2013. 5(11): p. 835-49. 

178. Spina, C.A., Anderson, J., Archin, N.M., Bosque, A., Chan, J., Famiglietti, M., Greene, W.C., Kashuba, A., Lewin, S.R., Margolis, D.M., Mau, M., Ruelas, D., Saleh, S., Shirakawa, K., Siliciano, R.F., Singhania, A., Soto, P.C., Terry, V.H., Verdin, E., Woelk, C., Wooden, S., Xing, S., and Planelles, V., An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog, 2013. 9(12): p. e1003834. 

177. Rardin, M.J., Newman, J.C., Held, J.M., Cusack, M.P., Sorensen, D.J., Li, B., Schilling, B., Mooney, S.D., Kahn, C.R., Verdin, E., and Gibson, B.W., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A, 2013. 110(16): p. 6601-6. 

176. Gut, P. and Verdin, E., Rejuvenating SIRT1 activators. Cell Metab, 2013. 17(5): p. 635-7. 

175. Gut, P. and Verdin, E., The nexus of chromatin regulation and intermediary metabolism. Nature, 2013. 502(7472): p. 489-98. 

174. Gut, P., Baeza-Raja, B., Andersson, O., Hasenkamp, L., Hsiao, J., Hesselson, D., Akassoglou, K., Verdin, E., Hirschey, M.D., and Stainier, D.Y., Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol, 2013. 9(2): p. 97-104. 

173. Shirakawa, K., Chavez, L., Hakre, S., Calvanese, V., and Verdin, E., Reactivation of latent HIV by histone deacetylase inhibitors.  Trends Microbiol, 2013. 21(6): p. 277-85. 

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172. Shimazu, T., Hirschey, M.D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C.A., Lim, H., Saunders, L.R., Stevens, R.D., Newgard, C.B., Farese, R.V., Jr., de Cabo, R., Ulrich, S., Akassoglou, K., and Verdin, E., Suppression of oxidative stress by beta- hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science, 2013. 339(6116): p. 211-4. 

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171. Calvanese, V., Chavez, L., Laurent, T., Ding, S., and Verdin, E., Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology, 2013. 446(1-2): p. 283-92. 

170. Boehm, D., Calvanese, V., Dar, R.D., Xing, S., Schroeder, S., Martins, L., Aull, K., Li, P.C., Planelles, V., Bradner, J.E., Zhou, M.M., Siliciano, R.F., Weinberger, L., Verdin, E., and Ott, M., BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle, 2013. 12(3): p. 452-62. 

169. Wirth, M., Karaca, S., Wenzel, D., Ho, L., Tishkoff, D., Lombard, D.B., Verdin, E., Urlaub, H., Jedrusik-Bode, M., and Fischle, W., Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion, 2013. 13(6): p. 705-20. 

168. Bharathi, S.S., Zhang, Y., Mohsen, A.W., Uppala, R., Balasubramani, M., Schreiber, E., Uechi, G., Beck, M.E., Rardin, M.J., Vockley, J., Verdin, E., Gibson, B.W., Hirschey, M.D., and Goetzman, E.S., Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem, 2013. 288(47): p. 33837-47. 

167. Alhazzazi, T.Y., Kamarajan, P., Verdin, E., and Kapila, Y.L., Sirtuin-3 (SIRT3) and the  Hallmarks of Cancer. Genes Cancer, 2013. 4(3-4): p. 164-71. 

166.  Peixoto, P., Castronovo, V., Matheus, N., Polese, C., Peulen, O., Gonzalez, A., Boxus, M., Verdin, E., Thiry, M., Dequiedt, F., and Mottet, D., HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell Death Differ, 2012. 19(7): p. 1239-52. 

165. Pan, Y., Nishida, Y., Wang, M., and Verdin, E., Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology, 2012. 58(6): p. 524-30. 

164. Schilling, B., Rardin, M.J., MacLean, B.X., Zawadzka, A.M., Frewen, B.E., Cusack, M.P., Sorensen, D.J., Bereman, M.S., Jing, E., Wu, C.C., Verdin, E., Kahn, C.R., Maccoss, M.J., and Gibson, B.W., Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics, 2012. 11(5): p. 202-14.

163. Schroder, S., Cho, S., Zeng, L., Zhang, Q., Kaehlcke, K., Mak, L., Lau, J., Bisgrove, D., Schnolzer, M., Verdin, E., Zhou, M.M., and Ott, M., Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem, 2012. 287(2): p. 1090-9. 

162. Newman, J.C., He, W., and Verdin, E., Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem, 2012. 287(51): p. 42436-43. 

161. Maurer, B., Rumpf, T., Scharfe, M., Stolfa, D.A., Schmitt, M.L., He, W., Verdin, E., Sippl, W., and Jung, M., Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett, 2012. 3(12): p. 1050-3. 

160. Kwon, H.S., Lim, H.W., Wu, J., Schnolzer, M., Verdin, E., and Ott, M., Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol, 2012. 188(6): p. 2712-21. 

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159. Kasler, H.G., Lim, H.W., Mottet, D., Collins, A.M., Lee, I.S., and Verdin, E., Nuclear export of histone deacetylase 7 during thymic selection is required for immune self- tolerance. EMBO J, 2012. 31(23): p. 4453-65. 

158. Kamarajan, P., Alhazzazi, T.Y., Danciu, T., D'Silva N, J., Verdin, E., and Kapila, Y.L., Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer, 2012. 118(23): p. 5800-10. 

157. Jang, Y.C., Liu, Y., Hayworth, C.R., Bhattacharya, A., Lustgarten, M.S., Muller, F.L., Chaudhuri, A., Qi, W., Li, Y., Huang, J.Y., Verdin, E., Richardson, A., and Van Remmen, H., Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell, 2012. 11(5): p. 770-82. 

156. Ismail, H., Mofarrahi, M., Echavarria, R., Harel, S., Verdin, E., Lim, H.W., Jin, Z.G., Sun, J., Zeng, H., and Hussain, S.N., Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77. Arterioscler Thromb Vasc Biol, 2012. 32(7): p. 1707-16. 

155. International, A.S.S.W.G.o.H.I.V.C., Deeks, S.G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., Chomont, N., Chun, T.W., Churchill, M., Di Mascio, M., Katlama, C., Lafeuillade, A., Landay, A., Lederman, M., Lewin, S.R., Maldarelli, F., Margolis, D., Markowitz, M., Martinez-Picado, J., Mullins, J.I., Mellors, J., Moreno, S., O'Doherty, U., Palmer, S., Penicaud, M.C., Peterlin, M., Poli, G., Routy, J.P., Rouzioux, C., Silvestri, G., Stevenson, M., Telenti, A., Van Lint, C., Verdin, E., Woolfrey, A., Zaia, J., and Barre- Sinoussi, F., Towards an HIV cure: a global scientific strategy. Nat Rev Immunol, 2012. 12(8): p. 607-14. 

154. He, W., Newman, J.C., Wang, M.Z., Ho, L., and Verdin, E., Mitochondrial sirtuins: regulators of protein acylation and metabolism.
Trends Endocrinol Metab, 2012. 23(9): p. 467-76. 

153. Hakre, S., Chavez, L., Shirakawa, K., and Verdin, E., HIV latency: experimental systems and molecular models. FEMS Microbiol Rev, 2012. 36(3): p. 706-16. 

152. Gallastegui, E., Marshall, B., Vidal, D., Sanchez-Duffhues, G., Collado, J.A., Alvarez- Fernandez, C., Luque, N., Terme, J.M., Gatell, J.M., Sanchez-Palomino, S., Munoz, E., Mestres, J., Verdin, E., and Jordan, A., Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1. J Virol, 2012. 86(7): p. 3795-808. 

151. Fritz, K.S., Galligan, J.J., Hirschey, M.D., Verdin, E., and Petersen, D.R., Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res, 2012. 11(3): p. 1633-43. 

150. Deeks, S.G., Verdin, E., and McCune, J.M., Immunosenescence and HIV. Curr Opin Immunol, 2012. 24(4): p. 501-6. 

149. Bonezzi, K., Belotti, D., North, B.J., Ghilardi, C., Borsotti, P., Resovi, A., Ubezio, P., Riva, A., Giavazzi, R., Verdin, E., and Taraboletti, G., Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies. Neoplasia, 2012. 14(9): p. 846-54. 

148. Weir, H.J., Murray, T.K., Kehoe, P.G., Love, S., Verdin, E.M., O'Neill, M.J., Lane, J.D., and Balthasar, N., CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. PLoS One, 2012. 7(11): p. e48225. 

147. Streeper, R.S., Grueter, C.A., Salomonis, N., Cases, S., Levin, M.C., Koliwad, S.K., Zhou, P., Hirschey, M.D., Verdin, E., and Farese, R.V., Jr., Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY), 2012. 4(1): p. 13-27. 

146. Sinclair, D. and Verdin, E., The longevity of sirtuins. Cell Rep, 2012. 2(6): p. 1473-4. 

145. Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., Zwaans, B.M., Tishkoff, D., Ho, L., Lombard, D., He, T.C., Dai, J., Verdin, E., Ye, Y., and Zhao, Y., The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics, 2011. 10(12): p. M111 012658. 

144. Alhazzazi, T.Y., Kamarajan, P., Joo, N., Huang, J.Y., Verdin, E., D'Silva, N.J., and Kapila, Y.L., Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer, 2011. 117(8): p. 1670-8. 

143. Alhazzazi, T.Y., Kamarajan, P., Verdin, E., and Kapila, Y.L., SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta, 2011. 1816(1): p. 80-8. 

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142. Hirschey, M.D., Shimazu, T., Jing, E., Grueter, C.A., Collins, A.M., Aouizerat, B., Stancakova, A., Goetzman, E., Lam, M.M., Schwer, B., Stevens, R.D., Muehlbauer, M.J., Kakar, S., Bass, N.M., Kuusisto, J., Laakso, M., Alt, F.W., Newgard, C.B., Farese, R.V., Jr., Kahn, C.R., and Verdin, E., SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell, 2011. 44(2): p. 177-90. 

141. Hirschey, M.D., Shimazu, T., Huang, J.Y., Schwer, B., and Verdin, E., SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol, 2011. 76: p. 267-77. 

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140. Rafati, H., Parra, M., Hakre, S., Moshkin, Y., Verdin, E., and Mahmoudi, T., Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol, 2011. 9(11): p. e1001206. 

139. Hirschey, M.D., Shimazu, T., Capra, J.A., Pollard, K.S., and Verdin, E., SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY), 2011. 3(6): p. 635-42. 

138. Jing, E., Emanuelli, B., Hirschey, M.D., Boucher, J., Lee, K.Y., Lombard, D., Verdin, E.M., and Kahn, C.R., Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A, 2011. 108(35): p. 14608-13. 

137. Hakre, S., Chavez, L., Shirakawa, K., and Verdin, E., Epigenetic regulation of HIV latency. Curr Opin HIV AIDS, 2011. 6(1): p. 19-24. 

136. Chavez, L., Kauder, S., and Verdin, E., In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods, 2011. 53(1): p. 47-53. 

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135. Kasler, H.G., Young, B.D., Mottet, D., Lim, H.W., Collins, A.M., Olson, E.N., and Verdin, E., Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double- positive thymocytes. J Immunol, 2011. 186(8): p. 4782-93. 

134. Parra, M. and Verdin, E., Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol, 2010. 10(4): p. 454-60. 

133. Trono, D., Van Lint, C., Rouzioux, C., Verdin, E., Barre-Sinoussi, F., Chun, T.W., and Chomont, N., HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science, 2010. 329(5988): p. 174-80. 

132. Pagans, S., Kauder, S.E., Kaehlcke, K., Sakane, N., Schroeder, S., Dormeyer, W., Trievel, R.C., Verdin, E., Schnolzer, M., and Ott, M., The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe, 2010. 7(3): p. 234-44. 

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131. Hirschey, M.D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D.B., Grueter, C.A., Harris, C., Biddinger, S., Ilkayeva, O.R., Stevens, R.D., Li, Y., Saha, A.K., Ruderman, N.B., Bain, J.R., Newgard, C.B., Farese, R.V., Jr., Alt, F.W., Kahn, C.R., and Verdin, E., SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature, 2010. 464(7285): p. 121-5. 

130. Verdin, E., Hirschey, M.D., Finley, L.W., and Haigis, M.C., Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci, 2010. 35(12): p. 669-75. 

129. Ott, M. and Verdin, E., HAT trick: p300, small molecule, inhibitor. Chem Biol, 2010. 17(5): p. 417-8. 

128. Huang, J.Y., Hirschey, M.D., Shimazu, T., Ho, L., and Verdin, E., Mitochondrial sirtuins. Biochim Biophys Acta, 2010. 1804(8): p. 1645-51. 

127. Qiu, X., Brown, K., Hirschey, M.D., Verdin, E., and Chen, D., Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab, 2010. 12(6): p. 662-7. 

126. Blagosklonny, M.V., Campisi, J., Sinclair, D.A., Bartke, A., Blasco, M.A., Bonner, W.M., Bohr, V.A., Brosh, R.M., Jr., Brunet, A., Depinho, R.A., Donehower, L.A., Finch, C.E., Finkel, T., Gorospe, M., Gudkov, A.V., Hall, M.N., Hekimi, S., Helfand, S.L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H.D., Peeper, D.S., Rando, T.A., Rudolph, K.L., Sassone-Corsi, P., Serrano, M., Sharpless, N.E., Skulachev, V.P., Tilly, J.L., Tower, J., Verdin, E., and Vijg, J., Impact papers on aging in 2009. Aging (Albany NY), 2010. 2(3): p. 111-21.

125. Saunders, L.R., Sharma, A.D., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., Willenbring, H., and Verdin, E., miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY), 2010. 2(7): p. 415-31. 

124. Baur, J.A., Chen, D., Chini, E.N., Chua, K., Cohen, H.Y., de Cabo, R., Deng, C., Dimmeler, S., Gius, D., Guarente, L.P., Helfand, S.L., Imai, S., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., McBurney, M., Nabeshima, Y., Neri, C., Oberdoerffer, P., Pestell, R.G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D.A., Steegborn, C., Tatar, M., Tissenbaum, H.A., Tong, Q., Tsubota, K., Vaquero, A., and Verdin, E., Dietary restriction: standing up for sirtuins. Science, 2010. 329(5995): p. 1012-3; author reply 1013-4. 

123. Malik, S., Jiang, S., Garee, J.P., Verdin, E., Lee, A.V., O'Malley, B.W., Zhang, M., Belaguli, N.S., and Oesterreich, S., Histone deacetylase 7 and FoxA1 in estrogen- mediated repression of RPRM. Mol Cell Biol, 2010. 30(2): p. 399-412. 

122. Yan, W., Si, Y., Slaymaker, S., Li, J., Zheng, H., Young, D.L., Aslanian, A., Saunders, L., Verdin, E., and Charo, I.F., Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem, 2010. 285(41): p. 31418-26. 

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